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Align your sequence(s)

thymidylate synthase

class : alpha plus beta number of structures : 5 average size : 285 average PID : 46 %

PDB
code
start
residue
start
chain
end
residue
end
chain
name source resolution R-factor
4tms rasmol 1 - 316 - thymidylate synthase Lactobacillus casei 2.40 19.3
3tms rasmol 1 - 264 - thymidylate synthase Escherichia coli 2.10 22.0
1tis rasmol 1 - 286 - thymidylate synthase Bacteriophage T4 3.10 19.9
2tsr rasmol 21 A 301 A thymidylate synthase Rattus norvegicus 2.60 16.2
1bkp rasmol 2 A 279 A thymidylate synthase A Bacillus subtilis 1.70 15.1
pir | ali | malform | joy-html | colour postscript | postscript | superimposed coordinates (RasMol)

external links
PFAM : thymidylat_synt  
other info key to JOY annotation | show related PDB structures

                           10        20        30        40        50  
4tms   (   1 )     mlEqpYLdLAkkVldeGhfk---pdrt-------htgTySifghqMrFd
3tms   (   1 )       MkqYleLMqkVldeGtqk---ndrt-------gtgTlSifghqMrFn
1tis   (   1 )       mkqYqdlikdIfeNgyet---ddrt-------gtgtialfgskLrWd
2tsra  (  21 )    qhgElqYlrqVehImrcGfkk---edrt-------gtgTlsvfgmqArYs
1bkpa  (   2 )    tqFDkqYnsiIkdIinnGisdeefdvrtkWdsdgtpAhtlsviskqMrFd
                      aaaaaaaaaaaaa bbb                 bbbbbbbbbbbb

                           60        70        80        90        100 
4tms   (  40 )    LskgFPLLTTkkVpfglIkSeLLWfL-hgdtnIrfLLqh-------rNhi
3tms   (  38 )    LqdgFPLVTTkrchlrsIIHELLWFL-qgdtniayLhen-------nVti
1tis   (  38 )    LtkgFPAvttkklawkaCIAELIWFL-sgstnVndLrliQhdsliqgkTv
2tsra  (  61 )    LrdeFPLLTTkrVfwkGVLeeLlWFI-kGsTnAkeLssk-------gVri
1bkpa  (  52 )    Ns-eVPILTTkkVawktAIkeLLWIWqlksndVndLnmm-------gVhi
                                 aaaaaaaaaaa       aaaa             

                           110       120       130       140       150 
4tms   (  82 )    wDewAFekwvksdeyhgpdMtdfghrsqkdpefaavYheemakFddrVlh
3tms   (  80 )    wdewAde-------------------------------------------
1tis   (  87 )    Wdenye-nqAkdlgyh----------------------------------
2tsra  ( 103 )    wdanGsrdfLdslgfs----------------------------------
1bkpa  (  94 )    wdqwkqe-------------------------------------------
                                                                    

                           160       170       180       190       200 
4tms   ( 132 )    ddaFAakYGdLglVyGsqWrawhtsk----------gdtidqLgdvIeqI
3tms   (  87 )    -------ngdLgpVYGkQWrawptpd----------grhidqIttVlnqL
1tis   ( 102 )    -------sGeLgpIYGkQWrdfg---------------gvdqIieVIdrI
2tsra  ( 119 )    ----arqegDLGPVYGFQWrhfga--dYkdMdsdysgqgvdqLqkVIdtI
1bkpa  ( 101 )    -------dgtIghAyGfQLgkk----nrslng-----ekvDqVdyLlhqL
                                aaaaaa                     aaaaaaaaa

                           210       220       230       240       250 
4tms   ( 172 )    kthpysrrLiVsAwnpedvptmalpPchtlYqFyVndgkLsLqLyQrsAd
3tms   ( 120 )    kndpdsrrIiVsAwnvgeldkMalaPchafFqFyvadgkLsCqLyQrsCd
1tis   ( 130 )    kklpndrrQiVsAwnpaelkyMAlpPchmfYqFnvrngyLdLqWyQrsVD
2tsra  ( 163 )    ktnpddrrIiMcAwnpkdlplMAlpPchalCqFyvvngeLsCqLyQrsGd
1bkpa  ( 135 )    knnpssrrHiTmLwnpdeldaMaltPcVyeTqWyVkhgkLhLeVrArsNd
                  aa       bbb      333      bbbbbbbbb  bbbbbbbbbbbb

                           260       270       280       290       300 
4tms   ( 222 )    IFlgVPfnIAsYALLThLVAheCglevgeFiHtFGdAhLyvnHldqIkeQ
3tms   ( 170 )    VFlgLPfnIASYALLVhMMAqQCdlevgdFvWtGGdThLysnHmdqThlQ
1tis   ( 180 )    VflgLpfnIAsYAtLVhiVAkMCnlipGdLiFsGGnThIymnhveqckei
2tsra  ( 213 )    MglgVpfnIASYALLTyMIAhITglqpGdFvHtLGdAhIylnhiepLkiQ
1bkpa  ( 185 )    MAlgNPfnVFQYNVLQrMIAqVTgyelgeYiFnIgdChVytrHidnLkiQ
                      aaaaaaaaaaaaaaaaaaa  bbbbbbbbbbbbbbb333aaaaaaa

                           310       320       330       340       350 
4tms   ( 272 )    lsrtprpaPtLqLnpdkh------------dIfdFdmkdIkllnydPypa
3tms   ( 220 )    lsreprplPkLiikrkPe------------sIfdYrfeDFeiegydPhpg
1tis   ( 230 )    lrrepkelCelvisglpykFrylsTkeQLkyVlklrpkdFvLnnyvshpp
2tsra  ( 263 )    lqreprpFPkLrilrkVe------------tIddFkveDFqiegynphpt
1bkpa  ( 235 )    mereqfeAPeLwinpevk------------dFydFtiddFkLinYkhgdk
                           bbbb                  333  333bbbb       

                         
4tms   ( 310 )    ikApvAv
3tms   ( 258 )    ikApvai
1tis   ( 280 )    ikgkmav
2tsra  ( 301 )    i      
1bkpa  ( 273 )    llFevAv
                         


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