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Align your sequence(s)

Serine/Threonine protein kinases, catalytic domain

class : alpha plus beta number of structures : 15 average size : 320 average PID : 26 %

PDB
code
start
residue
start
chain
end
residue
end
chain
name source resolution R-factor
1csn rasmol 6 - 298 - casein kinase I Schizosaccharomyces pombe 2.00 20.70
1cki rasmol 1 A 304 A casein kinase I delta isoform Rattus norvegicus 2.30 19.3
1a06 rasmol 10 - 316 - calcium/calmodulin-dependent protein kinase type I Rattus norvegicus 2.5 20.1
1phk rasmol 15 - 291 - phosphorylase kinase Oryctolagus cuniculus 2.20 21.00
1cdk rasmol 8 A 350 A cAMP-dependent protein kinase Sus scrofa 2.0 19.7
1koa rasmol 5915 - 6264 - twitchin kinase fragment Caenorhabditis elegans 3.3 25.1
1kob rasmol 23 A 375 A twitchin kinase fragment Aplysia californica 2.3 19.99
1tki rasmol 18 A 338 A titin Homo sapiens 2.0 20.7
1jnk rasmol 45 - 400 - mitogen-activated protein kinase 10 (c-jun n-terminal kinase 3) Homo sapiens 2.3 22.2
1p38 rasmol 4 - 354 - mitogen-activated protein kinase 14 (mitogen-activatedprotein kinase p38) Mus musculus 2.10 21.2
3erk rasmol 6 - 355 - mitogen-activated protein kinase 2 (erk2) Rattus norvegicus 2.1 20.6
1hcl rasmol 1 - 298 - cyclin dependent kinase 2 Homo sapiens 1.80 18.10
1blx rasmol 5 A 309 A cyclin-dependent kinase 6 Homo sapiens 1.9 20
1lr4 rasmol 7 A 333 A protein kinase ck2 Zea mays 2.00 19.5
1b6c rasmol 175 B 500 B TGF-beta receptor type I Homo sapiens 2.6 24.9
pir | ali | malform | joy-html | colour postscript | postscript | superimposed coordinates (RasMol)

external links
SMART : S_TKc  
PFAM : pkinase_C  pkinase  
other info key to JOY annotation | show related PDB structures

                           10        20        30        40        50  
1csn   (   6 )                                                 nvVGv
1ckia  (   1 )                                               melrVgn
1a06   (  10 )                                     wkqaed------I--rd
1phk   (  15 )                                                 F--ye
1cdka  (   8 )            kgseqesvkeflakakedFlkkwenpaqnta------h--ld
1koa   (5915 )                    ydnyvfdIwkqyypqpVeikhdh------v--ld
1koba  (  23 )                 indydkfyediwkkyvpqpVevkqgs------v--yd
1tkia  (  18 )                                         ke------L--ye
1jnk   (  45 )    d-nqfysvevg---------------------dstFtVl----------k
1p38   (   4 )    erptFyrqeln---------------------ktiWeVP----------e
3erk   (   6 )       aagpemvr---------------------gqvFdVg----------p
1hcl   (   1 )                                                    me
1blxa  (   5 )                                       glcr------a--dq
1lr4a  (   7 )           skArvyadvNvlrp----keywdyealtvqwg------e--qd
1b6cb  ( 175 )                       ttLkdliydmttsgsGSGLpllvqrtI--Ar
                                                                    

                           60        70        80        90        100 
1csn   (  11 )    hYkVgrrigeg---sfGvIfeGtnllnn-qqVAIKfEprrs---------
1ckia  (  11 )    ryrlgrkigsg---sfgdiylGtdiaag-eeVAIKlecvkt---------
1a06   (  19 )    iYdfrdvLgt-gafse--viLAedkrtq-klVaIkciak           
1phk   (  18 )    nYepkeilgr-G--vsSvVrrCihkptc-keyAVKiIdVtgggsfsaeev
1cdka  (  42 )    qFerikTLGt-g--sfGrVMLVkhketg-nhfAMKILdKqkVvk------
1koa   (5941 )    hYdiheeLgtG---aFGvVhrVteratg-nnFAAKfVmTph---------
1koba  (  52 )    yYdIleeLgsG---aFgvVhrCvekatg-rvFVAKfInTpy---------
1tkia  (  23 )    kYmiaedLgrg---efGiVhrCvetssk-ktyMAKfVkVkg---------
1jnk   (  63 )    rYqnLkpigsg---aqgiVCaAyDavld-rnVAIKkLs-------rPFqn
1p38   (  23 )    rYqnLspvgsg---ayGsvCAAfDtktg-hrVaVkkls-------rPFqs
3erk   (  22 )    rYtnlsyigeg---aygMvCsAyDnlnk-vrVAIkkIs--------Pfeh
1hcl   (   3 )    nFqkvekigeg---tygvvykArnklt-gevVaLkkIr      t-----
1blxa  (  12 )    qYecvaeigeg---ayGkvfkArDlknggrfValkrVr------Vqtge-
1lr4a  (  38 )    dyevvrkvgrg---kysevfeGinvnnn-ekCIIKiLk------pvk---
1b6cb  ( 204 )    tIvlqesigkg---rfgevwrGkwr---geeVaVkiFs------------
                   bbbbbbbbb       bbbbbbb      bbbbbbb             

                           110       120       130       140       150 
1csn   (  48 )    --dApqLrdEyrtYklLa--gctGIPnvyyfgqeg------lhnVLVIdl
1ckia  (  48 )    --khpqLhiEskIYkmMq--ggvGIPtIrwcgaeg------dynVMVmel
1a06   (  64 )           eneiavlhkI---khpnIvaLddIyeSg------ghlyLImqL
1phk   (  64 )    qelreaTlkEVdILrkV--sghpnIIqLkdtyetn------tfFFLVFdl
1cdka  (  82 )    lkqiehTlnEKrILqAV---nFpFLVkLeySFkdn------sNLYMVMey
1koa   (5978 )    esdketVrkEIqtMsvL---rhptLVnLhdAFedd------neMVMIYEF
1koba  (  89 )    pldkytVkneIsIMnqL---hhpkLINLhdAFedk------yeMVLILEF
1tkia  (  60 )    -tdQvlVkkeisiLniA---rhrNILhLhesfesm------eeLVMIFef
1jnk   ( 102 )    qthAkrAyrELvlMkcV---nHkNIIsLlnvFTpqktleeFqdVYLVMel
1p38   (  62 )    iihAkrtYreLrLlkhM---kHenVigLldVfTpArsleeFndVYLVthl
3erk   (  60 )    qtyCqrtLReIkILLrF---rHeNIIgIndIiR-aptieqMkdVYiVQdl
1hcl   (  42 )    egvpstAireIslLkel---nhpnIVkLldvihte------nkLyLVFef
1blxa  (  52 )    egmplstireVavLrhLEtfehpNVVrLfdvctvsrt-dretkLTLVfeh
1lr4a  (  75 )    ---kkkikrEIkILqnLc--gGpnIVkLldiVrdq----hsktpsLIFey
1b6cb  ( 236 )    sreerSwfREaeIYqtVm-LrhenIlgFIAadnkdn--gtwtqLWLVsdy
                      aaaaaaaaaaaa           bbbbbb         bbbbbb  

                           160       170       180       190       200 
1csn   (  88 )    Lg-pSLedLLdlcg-rkFsvkTVAMAAkqMLaRVqsIHe--------kSL
1ckia  (  88 )    Lg-psLedlFnfCs-rkFslkTVLLLAdqMIsRIeyIHs--------knf
1a06   (  98 )    VSGgeLfdrIve-k-gfYTErdAsrlIfQVLdAVkyLHd--------lgi
1phk   ( 106 )    MkkgeLfdylte-k-vtLsekeTrkiMraLLeVIcaLhk--------lnI
1cdka  ( 123 )    VpGGeMfsHLrr-i-grFsephArfYAAQIVLTFeYLhs--------LdL
1koa   (6019 )    MSGGELFekVAd-ehnkMsedeAVeYMrqVCkGLchMhe--------nny
1koba  ( 130 )    LSGgELFdrIAa-edykMsEaeVInYMrqACeGLkhMHe--------hsI
1tkia  ( 100 )    IsGlDIFerInt-safeLnEreIVsYVhqVCeALqfLhs--------hnI
1jnk   ( 149 )    Md-anLcqviq-m---eLdHerMSyLLYQMLCGIkHLHs--------Agi
1p38   ( 109 )    mg-adLnniVkcq---kltddhVqfLIyQILrGLkYIhs--------AdI
3erk   ( 106 )    Me-tDLyklLktq---hLsndhIcyFLyQILrGLkYIHs--------AnV
1hcl   (  83 )    Lh-qdLkkFmdaSaltgIplpLIkSYLfqLLqGLafChs--------hrv
1blxa  ( 101 )    vd-qdLttyLdkvpepgVptetIKdMMfqLLrGLdfLhs--------hrv
1lr4a  ( 116 )    VnntdfkvLypt-----LtdyDIryYIYeLLkALdyCHs--------qGI
1b6cb  ( 283 )    hehgsLfdyLnr---ytvtvegMIkLAlsTAsGLahLHmeivgtqGKpAI
                       aaaaa         aaaaaaaaaaaaaaaaaaaa           

                           210       220       230       240       250 
1csn   ( 128 )    VYrDIkPdNFLiGrpnsknanmIyVVDFgmvkfYrdpvtkqhipyrekkn
1ckia  ( 128 )    IHRdVkPdNFlMGl--gkkgnlVYIidFGlAkkYrdarthqhipyrenkn
1a06   ( 138 )    vHrdLkPenLLYysld--edskIMIsdf                      
1phk   ( 146 )    VHrdLkPeNILLdd-----dmnIkLTDFgfScqL-dpge--kl-----re
1cdka  ( 163 )    IYRDLkPeNLLIdq-----qGYIQVTDFgfAkrv-k--g--rT-----wt
1koa   (6060 )    VHLdLkPENIMFttk---rsneLKLIDFGLTahL-dpkq--sv-----kv
1koba  ( 171 )    VHLdIKpENIMCetk---kassVKIIDFGLAtkL-npde--iV-----kV
1tkia  ( 141 )    GHFDIrPenIIYqtr---rsstIKIIeFGqArqL-kpgd--nf-----rL
1jnk   ( 186 )    iHrDLkPsNIVvks-----dctLkILDFGla          sfmmtp---
1p38   ( 147 )    iHrdLkPsNLaVne-----dceLkIldFglar----------htddemtg
3erk   ( 144 )    LHRdLkPsnLLLnt-----tcdLkIcdFGlArvA-dpdh--dhtgf-lte
1hcl   ( 124 )    lHrdLkPqnLlInt-----eGaIkLadFGLA----rAfg--vpvrtythe
1blxa  ( 142 )    vHrdLkPqNIlVts-----sgqIkLadfgla----r--i--ysfqmalts
1lr4a  ( 153 )    MHRdVkPhNVmIdh----elrkLrLidWglAeFY-hpgk--eYnv-----
1b6cb  ( 330 )    AHrdLkSknIlVkk-----ngtCCIadLGLAVrhdsatdtIdiapnh---
                        333bbb          bbb                         

                           260       270       280       290       300 
1csn   ( 178 )    lsgtarYmSinTHlg------rEq---SrrDDLEaLGHVFMYFLrg----
1ckia  ( 178 )    ltgtarYaSintHlg------ieq---SRrDDLEsLGYVLMYFNlg----
1a06   ( 182 )        pgyvAPevlaq-----kp-y---skaVDCWSIGVIAYILLCG----
1phk   ( 183 )    vcgtpSylAPEIIeCsmndnhpGY---GkeVDMWsTGVIMYtLLAG----
1cdka  ( 198 )    lcgtpeyLAPEIils------kGY---nkAVDWWaLGVLIYEMAAG----
1koa   (6099 )    ttgtAeFaAPEvaeg------kpV---GyytDMWsVGVLSyILlSG----
1koba  ( 210 )    TtatAeFaAPEIvdr------epV---GfyTDMWaIGVLGYVLLSG----
1tkia  ( 180 )    lftapEYYAPEVHqh------dvV---staTDMWSLGTLVYVLLSG----
1jnk   ( 223 )    yvvtryyrAPEvIlg-m-----gy---keNVDIWSVGCIMGeMVrh----
1p38   ( 182 )    yvatRwYrAPEiMlnWm-----hy---nqtVDIWsVGCIMAeLltg----
3erk   ( 185 )    yvatrwyrAPeIMLnSk-----Gy---tksIDIWsVGCILAeMLsn----
1hcl   ( 163 )    -vvtlwyrAPEiLLgck-----yy---staVDIWsLGCIFAeMvtr----
1blxa  ( 179 )    vvvtlwyrAPEvLLqs------sy---atpVDLWSVGCIFAeMfrr----
1lr4a  ( 191 )    rVAsryFkGPELLVdlq-----dY---DYsLDMWSLGCMFAgMIFr----
1b6cb  ( 372 )    rvgTkRYmAPevLddsInmk---hFesFkraDIYaMGLVFWEIArrCsig
                           aaaa                aaaaaaaaaaaaaaaa     

                           310       320       330       340       350 
1csn   ( 215 )    -----s-LpWqglkaatnkqkyerIgekKqsTp----LreLCa-------
1ckia  ( 215 )    -----s-LpWqgl       kyerisekKmstp----ievLCk-------
1a06   ( 215 )    -----Y-pPFyde-------ndaklfeqIlkaeyefds------------
1phk   ( 226 )    -----s-pPFwhr-------kqmlmlrmImsgnyqfgs------------
1cdka  ( 235 )    -----y-pPFfad-------qpiqIyekIvsgkvrFps------------
1koa   (6136 )    -----l-sPFgge-------nddeTlrnVkscdwnmdd------------
1koba  ( 247 )    -----l-sPFage-------ddleTlqnVkrCdwefde------------
1tkia  ( 217 )    -----i-nPFlae-------tnqqiienImnaeytfde------------
1jnk   ( 260 )    -----k-iLFpgr-------dyidQWnkVIeqlGtpc-peFmkkL-qptv
1p38   ( 220 )    -----r-tlFpGt-------dhidQLklILrlVgTPg-aeLlkkIssesa
3erk   ( 223 )    -----r-piFpGk-------hyldQLnhIlgiLGsps-qedlncIinlkA
1hcl   ( 200 )    -----r-alFpGd-------seidQLfrIFrtLgtPd-evvWpgVt--sm
1blxa  ( 216 )    -----k-pLFrGs-------sdvdQLgkILdviglpg-eedwpr----dv
1lr4a  ( 229 )    -----kepFFyGh-------dnhdQLvkIAkvLgTdgLnvYLnkyrield
1b6cb  ( 419 )    gihedyqlPYydlVp--sdPsveeMrkvVceqklrPnipnrWq-------
                                       aaaaaaaaaa                   

                           360       370       380       390       400 
1csn   ( 248 )    --------------------------------gfpeEFykYMhyArnlaf
1ckia  ( 248 )    --------------------------------gypseFatYLnfCrslrf
1a06   ( 240 )    ----------------------------pyWddIsdsAkdFIrhLMekdp
1phk   ( 251 )    ----------------------------peWddysdtVkdLVsrFLvvqp
1cdka  ( 260 )    --------------------------------hFssdLkdLLrnLLqvdl
1koa   (6161 )    ----------------------------safsgisedGkdFirkLLladp
1koba  ( 272 )    ----------------------------daFssVspeAkdFIknLLqkep
1tkia  ( 242 )    ----------------------------eaFkeIsieAmdFVdrLLvker
1jnk   ( 295 )    rnyVenrpkyaGltfpkLFpdslFpadsehnklkAsqArdLLskMLvIdp
1p38   ( 256 )    rnyIqslaqmpkmnFanvFi------------ganplAvdLLekMLvldS
3erk   ( 259 )    rnyLlslphknkvpwnrlFp------------nAdskAldLLdkMLtfnp
1hcl   ( 234 )    pdykpsFpkwarqdfskvVp------------pLdedGrsLLsqMLhYdp
1blxa  ( 248 )    alprqafhsksaqpIekfVt------------dIdelGkdLLlkCLtfnp
1lr4a  ( 267 )    pqLealVgrhsrkpWlkfmna-------dNqhLVspeAidFLdkLLrYdH
1b6cb  ( 460 )    ------------------------------sceALrvMAkIMreCWyang
                                                     aaaaaaaaaa     

                           410       420       430       440       450 
1csn   ( 266 )    datP-----dydyLqgLFskVLerlnttedenFdWnll            
1ckia  ( 266 )    ddkP-----dYsyLrqlFrnLFhrqgfsydyvFDwnmlkfgaSr      
1a06   ( 262 )    ekRf-----tCeqAlqhpWIag--dtaldknihqsVseqIkknfa-kskw
1phk   ( 273 )    qkRy-----tAeeAlaHpFFqq--yv                        
1cdka  ( 278 )    tkRfGnlkdgvndIknHkWFa-------ttdwiaIyqrkveApfiPkfkg
1koa   (6183 )    ntRm-----tIhqAlehpWLtpgnapgrdsqipssrYtkirdsiktkyda
1koba  ( 294 )    rkRl-----tVhdAlehpWLk-gdhsnltsrIpssrYnkirqkikekyad
1tkia  ( 264 )    ksRm-----tAseAlqhpWLkqkierVstkvirtlkHrryYhtLikk--d
1jnk   ( 345 )    akRi-----sVddALqHpYInvwydpaeVe-ap-pp  qlder-------
1p38   ( 294 )    dkRi-----tAaqALahaYFaqyhdpddEpvAd-pYdqsFesr-------
3erk   ( 297 )    hkRi-----eveqALahpYLeqyydpsdEpiAeapFkFdmeld-------
1hcl   ( 272 )    nkRi-----sAkaAlahpFFq------dvtkpvPhLrl            
1blxa  ( 286 )    akRi-----sAysAlshpYFq------dlercken               
1lr4a  ( 310 )    qeRl-----tAleAmthpYFqqVraaen----------------------
1b6cb  ( 480 )    aaRl-----tAlrIkktLsqLsqqeg                        
                            aaaaa                                   

                           460       470       480      
1csn                                                    
1ckia                                                   
1a06   ( 304 )    kqaFnataVvrhm                         
1phk                                                    
1cdka  ( 321 )    pGdtsnFddyeeeeirvsi--------nekcgkeFseF
1koa   (6228 )    wpeplppLGrISnYSSlRkhrpqeysIrdafWdrsea 
1koba  ( 338 )    wpapqpaIGrIAnFSSLrkhrpqeyqIydsyFdrkeav
1tkia  ( 307 )    l-nMvvSAArIScggairsq--kgvsvAkVkvasi   
1jnk   ( 384 )    ehtieeWkelIykeVmn                     
1p38   ( 331 )    dllideWkslTydeVisfvpppl--------------d
3erk   ( 335 )    dlpkekLkelIfeeTarfqp-----------------g
1hcl                                                    
1blxa                                                   
1lr4a  ( 333 )    -------------------------------------s
1b6cb                                                   
                                                        


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